one-class logistic regression (OCLR)

ONE-CLASS DETECTION OF CELL STATES IN TUMOR SUBTYPES

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation 

PanCanStem Web

 

However, the challenge is to find them within samples containing mixtures of cell types of unknown proportions.

需要从一堆混合有未知细胞的细胞群中鉴定出我们想要的细胞。

We demonstrate that one-class models are able to identify specific cell types in heterogeneous cell populations better than their binary predictor counterparts.

We derive one-class predictors for the major breast and bladder subtypes and reaffirm the connection between these two tissues.

In addition, we use a one-class predictor to quantitatively associate an embryonic stem cell signature with an aggressive breast cancer subtype that reveals shared stemness pathways potentially important for treatment.

 

The resulting machine learning task is to build a model that can correctly rank the background samples containing the stemness signal above those that do not.

The accuracy is evaluated via Area under the ROC curve (AUC), which can be interpreted as the probability that the predictor correctly ranks a mixture sample above a non-mixture sample.

 

问题:

1. 到底什么是one class?

2. 与其他算法相比,有什么优点?

3. 我能应用到我的分析当中吗?

 

posted @ 2018-06-09 01:08 Bioinformatics 阅读(...) 评论(...) 编辑 收藏
TOP