This one took some time to weed out, but found that the Forefront ScanEngine had incorrectly flagged my welcome page in my Site Directory toVirusStatus=1 and was causing an Exception from HRESULT: 0x80041050error.

 

Solution:

 

  1. Open your SQL Server Management Studio and go to theContent Database where your default welcome page is returing the error(Usually WSS_Content_[someguid]).
  2. Create a new query and run:
    select *
    from AllDocs
    where (VirusStatus > 0) and (VirusStatus is not null)
  3. If you get any results this is your issue!  (Given that you don't actually have some virus in that file.)
  4. Run the next query: 
    update AllDocs 
    set VirusStatus = null 
    where (VirusStatus > 0) and (VirusStatus is not null)

 

Ref: http://geekswithblogs.net/MOSSParadox/archive/2007/07/05/Forefront-Security-and-MOSS--Exception-from-HRESULT-0x80041050.aspx