The web.config file for this project is missing the required DirectRequestModule.

将应用程序集的模式由集成改为经典即可.

或者如下操作

<system.webServer>
      <validation validateIntegratedModeConfiguration="false"/>
      <modules>
        <remove name="ScriptModule"/>
        <add name="DirectRequestModule" type="Ext.Net.DirectRequestModule, Ext.Net" />

      </modules>

    </system.webServer>