[转载]蛋白质序列数据库
| 3. Protein Sequence Databases |
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| 3.1. General sequence databases |
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EXProt |
Sequences of proteins with experimentally verified function |
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MIPS resources |
Munich Information Center for Protein Sequences databases |
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NCBI Protein database |
All protein sequences: translated from GenBank and imported from other protein databases |
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PA-GOSUB |
Protein sequences from model organisms, GO assignment and subcellular localization |
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PIR |
Protein Information Resource |
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PRF |
Protein research foundation database of peptides |
http://www.prf.or.jp/en/index.shtml |
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TCDB |
Transporter protein classification database |
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UniParc |
UniProt archive, a repository of all protein sequences |
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UniProt |
Universal Protein knowledgebase, combined information from Swiss-Prot, TrEMBL, and PIR |
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UniProtKB\Swiss-Prot |
Formerly SwissProt, part of the UniProt knowledgebase |
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UniProtKB\TrEMBL |
Now UniProt/TrEMBL, part of the UniProt knowledgebase |
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UniRef |
Clustered sets of related sequences from UniProt |
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UniSave |
UniProtKB Sequence/Annotation Version Archive |
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| 3.2. Protein properties |
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AAindex |
Physicochemical properties of amino acids |
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BindingDB |
Binding affinities of protein-ligand and other complexes |
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CyBase |
Proteins with cyclic backbones |
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dbPTM |
Information on post-translational modification of proteins |
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iProLINK |
Annotated literature sources for protein features and names |
http://pir.georgetown.edu/iprolink |
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MALISAM |
Manual alignments for structurally analogous motifs in proteins |
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MegaMotifbase |
Structural motifs in protein families and superfamilies |
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PIDD |
Protein inter-atomic distances database |
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PINT |
Protein-protein interactions thermodynamic database |
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PPD |
Experimentally-determined protein pKa values |
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PPT-DB |
Protein Property Prediction and Testing Database |
http://redpoll.pharmacy.ualberta.ca/PPT_DB/public_html/PPT_main.html |
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ProTherm |
Thermodynamic data for wild-type and mutant proteins |
http://gibk26.bse.kyutech.ac.jp/jouhou/protherm/protherm.html |
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PRTAD |
Protein residue torsion angle database |
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REFOLD |
Experimental data on protein refolding and purification |
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| 3.3. Protein localization and targeting |
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DBSubLoc - |
Database of protein Subcellular Localization |
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eSLDB |
eukaryotic proteins Subcellular Localization Database |
http://gpcr.biocomp.unibo.it/esldb |
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InterFil |
Human Intermediate Filament database |
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LOCATE |
Subcellular localization of mouse proteins |
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MiCroKit |
Midbody, Centrosome and Kinetochore proteins |
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MitoDrome |
Nuclear-encoded mitochondrial proteins of Drosophila |
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MitoRes |
Nuclear genes coding for mitochondrial proteins |
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NESbase |
Nuclear export signals database |
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NLSdb |
Nuclear localization signals |
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NMPdb |
Nuclear matrix associated proteins database |
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NOPdb: |
Nucleolar proteome database |
http://www.lamondlab.com/NOPdb/ |
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NPD |
Nuclear Protein Database |
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Nuclear Receptor Resource |
Nuclear receptor superfamily |
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NUREBASE |
Nuclear hormone receptors database |
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NURSA |
Nuclear receptor signaling atlas |
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PSORTdb |
Protein subcellular localization in bacteria |
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Secreted Protein DB |
Secreted proteins from human, mouse and rat |
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SUBA |
Subcellular localisation of Arabidopsis proteins |
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THGS |
Transmembrane Helices in Genome Sequences |
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TopDB |
Topology Data Bank of transmembrane proteins |
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Transmembrane Protein Database |
Transmembrane proteins with experimentally-characterized transmembrane topologies |
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| 3.4. Protein sequence motifs and active sites |
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ASC |
Active Sequence Collection |
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Blocks |
Alignments of conserved regions in protein families |
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COMe |
Co-Ordination of Metals etc. |
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CoPS |
Comprehensive peptide signature database |
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CSA |
Catalytic Site Atlas |
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eBLOCKS |
Highly conserved protein sequence blocks |
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eF-site |
Electrostatic surface of Functional site |
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eMOTIF |
Protein sequence motif determination and searches |
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FireDB |
Functionally important residues in protein structures |
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InterPro |
Integrated resource of protein families, domains and functional sites |
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Metalloprotein Site DB |
Metal-binding sites in metalloproteins |
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O-GLYCBASE |
O- and C-linked glycosylation sites in proteins |
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PDBSite |
3D structure of protein functional sites |
http://srs6.bionet.nsc.ru/srs6bin/cgi-bin/wgetz?-page+LibInfo+-newId+-lib+PDBSite |
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Phospho.ELM |
S/T/Y protein phosphorylation sites (former PhosphoBase) |
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Phospho3D |
3D structures of protein phosphorylation sites |
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PRINTS |
Hierarchical gene family fingerprints |
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PROMISE |
Prosthetic centers and metal ions in protein active sites |
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ProRule |
Functional and structural information on PROSITE profiles |
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PROSITE |
Biologically-significant protein patterns and profiles |
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ProTeus |
Signature sequences at the protein N- and C-termini |
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SitesBase |
Known ligand binding sites in the PDB |
http://www.modelling.leeds.ac.uk/sb/ |
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| 3.5. Protein domain databases; protein classification | |||
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ADDA |
Database of protein domain classification |
http://ekhidna.biocenter.helsinki.fi/sqgraph/pairsdb |
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BAliBASE |
Benchmark database for comparison of multiple sequence alignments |
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Benchmark |
Protein classification benchmark collection: training/test sets for machine learning |
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BIOZON |
Database of gene and protein familiy classification |
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CDD |
Conserved domain database, includes protein domains from Pfam, SMART, COG and KOG databases |
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CluSTr |
Clusters of UniProt Knowledgebase and IPI proteins |
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COG |
Clusters of orthologous groups of proteins |
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DomIns |
Database of Domain Insertions |
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eggNOG |
Evolutionary genealogy of genes: Non-supervised Orthologous Groups |
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EPGD |
Eukaryotic Paralog Group Database |
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EVEREST |
Automatically generated protein domain families |
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FunShift |
Functional divergence between the subfamilies of a protein domain family |
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FusionDB |
Database of bacterial and archaeal gene fusion events |
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Hits |
Database of protein domains and motifs |
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HSSP |
Homology-derived structures of proteins |
http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-page+LibInfo+-lib+HSSP |
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InterDom |
Putative protein domain interactions |
http://interdom.i2r.a-star.edu.sg/ |
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iProClass |
Integrated protein classification database |
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MulPSSM |
Multiple PSSMs of structural and sequence families |
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PairsDB |
Pairwise alignments of all sequences in UniProt |
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PALI |
Phylogeny and alignment of homologous protein structures |
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PANTHER |
Protein sequence evolution mapped to functions and pathways |
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Pfam |
Protein families: Multiple sequence alignments and profile hidden Markov models of protein domains |
http://pfam.sanger.ac.uk/ |
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PhyloFacts |
Phylogenomic analysis of protein families |
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PIRSF |
Family/superfamily classification of whole proteins |
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ProDom |
Protein domain families |
http://prodom.prabi.fr/ |
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ProtoMap |
Hierarchical classification of Swiss-Prot proteins |
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ProtoNet |
Hierarchical clustering of Swiss-Prot proteins |
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SBASE |
Protein domain sequences and tools |
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SIMAP |
Similarity matrix of proteins: precomputed similarity data |
http://mips.gsf.de/simap/ |
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SISYPHUS |
Structural alignments for proteins with non-trivial relationships |
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SMART |
Simple modular architecture research tool: signalling, extracellular and chromatin-associated protein domains |
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SUPFAM |
Grouping of sequence families into superfamilies |
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TIGRFAMs |
TIGR protein families adapted for functional annotation |
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| 3.6. Databases of individual protein families | |||
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ABCdb |
Archaeal and bacterial ABC transporter database |
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Aminoacyl-tRNA synthetases database |
Aminoacyl-tRNA synthetase database |
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Animal Toxin DB |
Database of animal toxins |
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ARAMEMNON |
Arabidopsis thaliana membrane proteins and transporters |
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BACTIBASE |
Database of bacteriocin natural antimicrobial peptides |
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BacTregulators |
Transcriptional regulators of AraC and TetR families |
No longer maintained |
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BANMOKI |
Database of bacterial nucleoside monophosphate kinases |
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ChromDB |
Chromatin-associated proteins in a broad range of organisms |
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cpnDB |
Chaperonin database |
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CREMOFAC |
Database of chromatin remodeling factors |
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CSDBase |
Cold Shock Domain database |
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CyMoBase |
Cytoskeletal and motor proteins database |
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DB-PABP |
Experimentally characterized polyanion-binding proteins |
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DCCP |
Database of Copper-Chelating Proteins |
http://sdbi.sdut.edu.cn/DCCP/en/index.php |
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Defensins Knowledgebase |
Antimicrobial peptides of the defensin family |
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DExH/D Family DB |
DEAD-box, DEAH-box and DExH-box proteins |
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DSD |
Database of dehydrogenase stereospecificities |
http://www.jenner.ac.uk/DSD |
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Endogenous GPCR List |
G protein-coupled receptors; expression in cell lines |
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EROP-Moscow |
Database of Endogenous Regulatory OligoPeptides |
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ESTHER |
Esterases and other alpha/beta hydrolase enzymes |
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FUNPEP |
Low-complexity peptides capable of forming amyloid plaque |
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GPCRDB |
G protein-coupled receptors database |
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gpDB |
G-protein database: G-proteins and their interaction with GPCRs |
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Heme Protein DB |
Heme protein structure, heme type, axial ligands, and heme protein reduction potential (Em) values |
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Histone Database |
Histone fold sequences and structures |
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HIV RT and Protease Sequence Database |
HIV reverse transcriptase and protease sequences |
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Homeobox Page |
Homeobox proteins, classification, and evolution |
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Homeodomain Resource |
Homeodomain sequences, structures, and related genetic and genomic information |
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InBase |
Inteins (protein splicing elements) database: properties, sequences, bibliography |
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KinG |
Kinases in Genomes: Ser/Thr/Tyr kinases encoded in the completely sequenced genomes |
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Knottin database |
Database of knottins, small proteins with an unusual "disulfide through disulfide" knot |
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LGICdb |
Ligand-gated ion channel subunit sequences database |
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Lipase Engineering DB |
Sequence, structure and function of lipases and esterases |
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LOX-DB |
Mammalian, invertebrate, plant and fungal lipoxygenases |
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MEROPS |
Database of proteolytic enzymes (peptidases) |
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NORINE |
Database of nonribosomal peptides |
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NucleaRDB |
Nuclear receptor superfamily |
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Olfactory Receptor DB |
Sequences for olfactory receptor-like molecules |
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Peptaibol |
Peptaibol (antibiotic peptide) sequences |
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PhytoProt |
Clusters of (predicted) plant proteins |
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PLANT-PIs |
Plant protease inhibitors |
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PlantsP/PlantsT |
Plant proteins involved in phosphorylation and transport |
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PLPMDB |
Pyridoxal-5'-phosphate dependent enzymes mutations |
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ProLysED |
Database of bacterial protease systems |
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Prolysis |
Proteases and natural and synthetic protease inhibitors |
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Protein kinase resource |
Protein kinase resource: sequences, enzymology, genetics and molecular and structural properties |
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REBASE |
Restriction enzymes and associated methylases |
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RNAse P Database |
Ribonuclease P sequences, alignments and structures |
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RNRdb |
Ribonucleotide reductase database |
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RPG |
Ribosomal Protein Gene database |
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RTKdb |
Receptor Tyrosine Kinase database |
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SDAP |
Structural database of allergenic proteins and food allergens |
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SelenoDB |
Database of selenoprotein genes, proteins and SECIS elements |
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SENTRA |
Sensory signal transduction proteins |
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SEVENS |
7-transmembrane helix receptors (G-protein-coupled) |
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Telomerase database |
Sequences and structures of the RNA and protein subunits of telomerase, mutations of telomerase components |
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TransportDB |
Predicted membrane transporters in complete genomes, classified according to the TC classification system |
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VKCDB |
Voltage-gated K+ Channel Database |
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Wnt Database |
Wnt proteins and phenotypes |
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