ACR2024_官方预告基础科学热点: 细胞疗法，疼痛干预等

Investigators to Review New Discoveries in Cellular Therapy, Pain Mediation, and More
研究人员将回顾细胞疗法，疼痛干预等方面的新发现

November 1, 2024 2024年11月1日

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Investigators will showcase the strides they have made in furthering the understanding of several aspects of rheumatic diseases, including identifying new potential for cellular therapy, the interplay of the microbiome and immunology, and new approaches to pain mediation, in the basic science program during ACR Convergence 2024.
在ACR Convergence 2024期间的基础科学计划中, 研究人员将展示他们在进一步了解风湿性疾病的几个方面所取得的进展，包括确定细胞治疗的新潜力，微生物组和免疫学的相互作用，以及疼痛干预的新方法。

Anne Davidson, MBBS Anne Davidson，MBBS

“We have about two dozen basic science sessions planned on a broad range of topics reflecting new discoveries in multiple areas of rheumatology,” said Anne Davidson, MBBS, Professor of Molecular Medicine at the Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra Northwell Health, and Chair of the Basic Science Team for the Annual Meeting Planning Committee (AMPC). She highlighted some of the hot topics in this year’s scientific sessions.
“我们有大约二十多个基础科学专题会议计划用广泛的主题反映在风湿病学多个领域的新发现，” 安妮·戴维森说 (MBBS，分子医学教授在范斯坦医学研究所和Zucker医学院在霍夫斯特拉诺斯韦尔健康，和基础科学小组的主席为年会规划委员会（AMPC）)。她强调了今年科学会议的一些热门话题。

Two afternoon sessions on Monday, Nov. 18, will explore the delivery of therapeutics for rheumatic disease. Delivering the Goods at Nanoscale: Novel Biomaterials as Therapies for Autoimmune Diseases, 1–2 p.m. ET in Room 103AB, will discuss drug delivery using biomaterials. BiKEs, TriKEs, and Exotic CARs: Riding Therapy Into the Next Generation of Treatment, 3–4:30 p.m. in Hall D/E, will highlight CAR T-cell therapy, which employs a patient’s own immune cells to treat disease.
11月18日星期一下午的两个会议将探讨风湿性疾病的治疗方法。在纳米尺度上输送货物：新型生物材料作为自身免疫疾病的治疗方法，东部时间下午1点到2点在103 AB室，将讨论使用生物材料的药物输送。BiKE，TriKE和外来汽车：骑疗法进入下一代治疗，下午3-4时在大厅D/E，将突出CAR T细胞疗法，它采用患者自己的免疫细胞来治疗疾病。

“This will show people what the future might look like in cellular therapy,” Dr. Davidson said. “This year, we’re delving deeper into new development in this area that is going to progress and become available for many of our rheumatic diseases.”
戴维森博士说：“这将向人们展示细胞疗法的未来。今年，我们正在深入研究这一领域的新发展，这一领域将取得进展，并可用于我们的许多风湿性疾病。”

Multiple sessions will address the role of the microbiome in rheumatic disease. On Saturday, Nov. 16, A Case of Miscommunication: Perturbed Host-Microbe Crosstalk, will be from 3–4:30 p.m. in Room 102AB. On Monday, Don’t Bug Me: Microbial Metabolites Underlying Disease will be from 2:15–3:15 p.m. in Room 102AB.
多个会议将讨论微生物组在风湿性疾病中的作用。11月16日，星期六，下午3点到4点，在102AB室，一个误解的案例：干扰的宿主微生物串扰。星期一，不要打扰我：微生物代谢疾病的基础将从下午15点到15点在102AB室。

“The whole microbiome area is starting to move from descriptions of what the bacteria are to actual mechanisms of how they might be influencing immune function,” Dr. Davidson said.
戴维森博士说：“整个微生物组领域开始从描述细菌是什么转向它们如何影响免疫功能的实际机制。”

The understanding of how pain is mediated through various pain receptors also continues to evolve.
对疼痛如何通过各种疼痛受体介导的理解也在不断发展。

“Pain is still a frontier that we don’t deal with well enough,” Dr. Davidson said.
戴维森博士说：“疼痛仍然是一个我们处理得不够好的前沿问题。”

On Sunday, Nov. 17, SOTA: Living at the Synapse: It’s Time to Embrace Neuroimmune Cross Talk, 9–10 a.m. in Room 146C, will address how the neurologic and immune systems communicate. Another Sunday session, Chewing the Fat…and the Cartilage: Breakthroughs in Osteoarthritis Research, 10:30–11:30 a.m. in Room 102AB, will include a presentation on pain relief. Then on Monday, Inferno Within: The Role of Sensory Systems in Immune-Induced Exaggerated Pain, 1–2:30 p.m. in Room 146C, will highlight the emerging data on neurotransmitters, pain channels, and other molecules important in pain.
11月17日，星期日，SOTA：生活在突触：是时候拥抱神经免疫对话，上午9点至10点在146 C室，将阐明神经和免疫系统如何沟通。另一个星期天的会议，咀嚼脂肪......和软骨：骨关节炎研究的突破，上午10点到11点在102 AB室，将包括一个关于缓解疼痛的演讲。然后在星期一，地狱内：感觉系统在免疫诱导的夸大疼痛中的作用，下午1-2：30在146 C室，将突出神经递质，疼痛通道和其他疼痛重要分子的新兴数据。

Emerging concepts regarding the dynamics of aging, inflammation, and mitochondrial dysregulation will be featured in the Saturday session Mitochondria: Fueling Autoimmunity, 9–10 a.m. in Room 102AB, and the Monday session Inflammaging: Old Cells Die Hard, 10–11:30 a.m. in Room 143ABC.
关于衰老，炎症和线粒体失调的动态的新兴概念将在周六会议线粒体：燃料自身免疫，上午9-10点在房间102 AB，和周一会议炎症：老细胞死硬，上午10-11点在房间143 ABC。

State-of-the-Art (SOTA) sessions featuring a single speaker allow for a greater examination of a given topic, including the neuroimmunology session mentioned above. The basic science program includes two additional SOTA sessions. On Sunday, SOTA: Complement-Ary Functions for a T-Cell Enzyme: New Insights into Granzyme K will be from 10:30–11:30 a.m. in Ballroom A. On the final day of ACR Convergence, Tuesday, Nov. 19, SOTA: Busy Bs: Deciphering B Cell Contributions to Rheumatoid Synovitis will be from 9:30–10:30 a.m. in Room 144ABC.
最新技术水平（SOTA）会议由一位演讲者主讲，允许对给定主题进行更深入的研究，包括上述神经免疫学会议。基础科学计划包括两个额外的SOTA会议。周日，SOTA：T细胞酶的补体功能：对颗粒酶K的新见解将于上午10点至11点在A舞厅举行。11月19日星期二，ACR会议的最后一天，SOTA：忙碌的B：破译B细胞对类风湿性滑膜炎的贡献将于上午9：30-10：30在144 ABC房间举行。

“These are areas where there is a lot of data and the speaker can give the audience a proper overview of the area and show all of the new data,” Dr. Davidson said. “That’s why we’ve chosen topics that are closely relevant to our diseases.”
戴维森博士说：“这些领域有大量的数据，演讲者可以给听众一个适当的概述，并展示所有的新数据。”“这就是为什么我们选择了与我们的疾病密切相关的主题。

The Monday session XIST-ential: Sex-Biased Epigenetic Control of Systemic Lupus Erythematosus, 9–10 a.m. in Room 145AB, will discuss the role of the X chromosome in autoimmune disease.
星期一的会议XIST-ential：系统性红斑狼疮的性别偏见表观遗传控制，上午9-10点在145 AB室，将讨论X染色体在自身免疫性疾病中的作用。

“Women have a higher frequency of most autoimmune diseases, but on the plus side, they’re better protected from viral infections. We learned that during the COVID-19 pandemic,” Dr. Davidson said. “It’s always been a question of what is more important: hormones versus genetics. Now, there is new information about how the components of the inactivated X chromosome may work to influence the immune system in women in mediating more robust inflammation.”
“女性患大多数自身免疫性疾病的频率更高，但从好的方面来说，她们能更好地免受病毒感染。我们在COVID-19大流行期间了解到这一点，”戴维森博士说。“这一直是一个什么更重要的问题：激素与遗传学。现在，有新的信息表明，失活的X染色体的成分可能会影响女性的免疫系统，从而介导更强烈的炎症。

Additional basic science sessions
其他基础科学专题

Saturday, Nov 16 星期六，11月16日

• The JCR-ACR Scientific Session: At the Heart of the Inflamed Vessel: New Insights into Cardiovascular Disease and Vasculitis, 9–10 a.m. ET, Room 145AB
  JCR-ACR科学会议：炎症血管的核心：心血管疾病和血管炎的新见解，东部时间上午9点至10点，145 AB室

• GRASPing and cGASing at SSc Pathogenesis: Molecular Insights into Centromeres, Genes, and Beyond, 10–11:30 a.m. ET, Room 144ABC
  GRASPing和cGASing在SSc发病机制：着丝粒，基因和超越的分子见解，东部时间上午10-11：30，144 ABC室

• Fueling the Flame: New Mechanisms in Autoinflammatory Diseases, 10–11:30 a.m. ET, Room 103AB
  火上浇油：自身炎症性疾病的新机制，美国东部时间上午10-11：30，103 AB室

• ACE-ing the Test: Mechanistic Studies Enhance Clinical Trials  – The Autoimmunity Centers of Excellence Experience, 1–2:30 p.m. ET, Room 102AB
  ACE测试：机制研究增强临床试验-卓越经验的自身免疫中心，东部时间下午1-2：30，102 AB室

• From Womb to Rheum: Nonredundant Roles for Innate Lymphoid Cells in Inflammation, 2:15–3:15 p.m. ET, Room 152B
  从子宫到风湿：先天淋巴细胞在炎症中的非冗余作用，东部时间下午2：15-3：15，152 B室

• Bone Voyage: Inflammatory Bone Loss and Metabolism, 3–4:30 p.m. ET, Room 206
  骨航行：炎症性骨丢失和代谢，东部时间下午3-4：30，206室

Sunday, Nov 17 星期日，11月17日

• Hench Memorial Lecture — Synovial Fibroblast in Rheumatoid Arthritis: Searching for Targetable Mechanism, 1–2 p.m. ET, Room 145AB
  亨奇纪念讲座-风湿性关节炎滑膜成纤维细胞：寻找靶向机制，东部时间下午1-2点，145 AB室

• The Untouchable B Cell: Novel Insights into Antibody-Secreting Cells, 1–2:30 p.m. ET, Room 144ABC
  不可接触的B细胞：抗体分泌细胞的新见解，东部时间下午1-2：30，144 ABC室

• Where the Rubber Meets the Road: Exploring the Epithelial-Immune Cell Interplay Underlying Sjögren’s Syndrome, 3–4:30 p.m. ET, Room 144ABC
  橡胶遇到道路：探索干燥综合征背后的上皮免疫细胞相互作用，东部时间下午3-4：30，144 ABC室

Monday, Nov 18 11月18日星期一

• Gluck Memorial Lecture — Osteoimmunology: The Little Niche with Big Impact, 10:30–11:30 a.m. ET, Room 144ABC
  格鲁克纪念讲座-骨免疫学：小利基与大的影响，上午10：30-11：30东部时间，144 ABC室

• Gasping for Cellular Repair: New Insights Into Interstitial Lung Disease Pathogenesis and Treatment, 1–2:30 p.m. ET, Room 143ABC
  细胞修复的喘息：间质性肺疾病发病机制和治疗的新见解，东部时间下午1-2：30，143 ABC室

• Gout, Gout, Get Ready for a Bout: Here Come New Mechanisms to Knock You Out, 3–4:30 p.m. ET, Room 143ABC
  痛风，痛风，准备好一场比赛：这里来了新的机制来击倒你，下午3-4：30东部时间，143 ABC室

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